TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0262c/aac:

update plot	correlation	link to info on gene
Rv2970A/-	(cc=0.5404)	info on Rv2970A/-
Rv0997/-	(cc=0.4982)	info on Rv0997/-
Rv2330c/lppP	(cc=0.4974)	info on Rv2330c/lppP
Rv3523/ltp3	(cc=0.461)	info on Rv3523/ltp3
Rv3528c/-	(cc=0.4357)	info on Rv3528c/-
Rv2548/vapC19	(cc=0.4309)	info on Rv2548/vapC19
Rv3741c/-	(cc=0.4295)	info on Rv3741c/-
Rv2737A/-	(cc=0.42)	info on Rv2737A/-
Rv3210c/-	(cc=0.4116)	info on Rv3210c/-
Rv1207/folP2	(cc=0.4107)	info on Rv1207/folP2

Correlation of Rv0262c/aac with Rv1207/folP2

Normalized LFCs for Rv0262c/aac:
(description and provenance of datasets)

	Rv0262c/aac	Rv1207/folP2
Fe_supp_jason_reseq	0.586	-1.651
low_pH_jason_reseq	-0.368	-0.415
NO_jason_reseq	0.391	-2.83
B6_jason_reseq	-0.767	-0.964
MHCII_jason_reseq	-0.603	-1.368
Isoniazid02	1.157	0.118
Rifampicin4	1.205	0.772
Ethambutol3	0.879	2.741
Meropenem3	0.041	0.835
Vancomycin16	0.674	0.456
Rv2680_day32	2.426	-0.228
H37Rv_KO_MarP	1.376	1.136
hypoxia_3wks	0.044	-0.758
hypoxia_6wks	0.495	-1.263
glycerol	-0.123	-1.097
cholesterol	1.459	1.186
AJ	0.089	-1.153
Bibs02	0.902	0.758
Bibs02c	-0.041	0.476
BL6	-0.58	0.757
BL6a	1.53	0.664
BXD01	0.877	0.296
BXD010	2.333	2.245
BXD011	1.184	2.472
BXD03	2.031	1.603
BXD04	0.396	0.964
BXD05	2.602	1.861
BXD06	1.524	0.527
BXD07	2.382	0.923
BXD08	1.136	1.339
BXD09	1.659	1.095
CAST	0.0	0.0
CCcont	0.623	0.647
DS01	0.578	-0.968
DS02	0.083	0.684
DS04	1.307	-0.358
DS0c	-1.796	-1.284
GP01	-1.721	-0.118
GP02	-1.158	-0.91
GP0c	-2.018	-0.197
NOD	0.129	-1.22
NZO	-1.331	-1.503
PWK	0.112	0.698
H37Rv_KO_CtpC	2.607	0.406
H37Rv_KO_CtpD	0.049	0.684
H37Rv_KO_Rv1272	-1.592	0.557
H37Rv_KO_SugABC	0.387	1.301
H37Rv_KO_MbtN	0.88	0.234
Trans05	0.853	1.035
macrophage_unactivated	0.085	0.051
IL1	0.0	1.243
Rapamycin	0.826	0.368
Tcell	-0.427	0.622
GMCSF	0.977	-0.214
IFNab	1.261	0.78
IFNg	0.679	-1.713
IFNg_GMCSF1	-0.113	-1.175
Rv1432_day32	0.299	-1.172
Rv1565c_day32	-0.194	-1.641
secA2_input	2.336	-0.463
delta_Rv3594	-0.906	-0.369
delta_Rv3717	0.05	-1.617
delta_Rv3811	0.019	-1.581
delta_Rv0954	-0.282	-1.244
PonA1	-0.779	-0.382
EccD1_KO	0.97	0.516
EspI_KO	-0.271	-0.22
PE35_KO	-0.403	-0.767
PPE68_KO	-0.442	-1.017
glycerol2	1.424	-0.687
lignocerate	1.46	-0.82
oleate	0.529	0.723
phosphatidylcholine	1.13	-0.179
acetate	1.493	0.08
glucAc	0.412	-0.617
Rv0950ko	-0.145	-0.633
Rv1096ko	-0.193	-0.685
Rv3684ko	0.052	1.248
delta_otsA_trehalose	-2.049	-0.211